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Science 1 August 1975:
Vol. 189. no. 4200, pp. 390 - 393
DOI: 10.1126/science.1145209
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Articles

Science, Vol 189, Issue 4200, 390-393
Copyright © 1975 by American Association for the Advancement of Science

articles

Glomerular epithelium: structural alterations induced by polycations

MW Seiler, MA Venkatachalam, and RS Cotran

Perfusion of rat kidneys with the polycation protamine sulfate caused glomerular epithelial alterations resembling those observed in human and experimental nephrotic states. The changes included swelling, blunting, and flattening of epithelial foot processes, were accompanied by decreased stainability of glomerular anionic sites, and were largely reversed by subsequent perfusion with the polyanion heparin.


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