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Science 4 July 1975:
Vol. 189. no. 4196, pp. 45 - 46
DOI: 10.1126/science.166434
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Articles

Science, Vol 189, Issue 4196, 45-46
Copyright © 1975 by American Association for the Advancement of Science

articles

Cell rigidity: Effect on concanavalin A-mediated agglutinability of fibroblasts after fixation

DA Gibson, MD Marquardt, and JA Gordon

A quantitative hemadsorption assay distinguishes the effects of membrane fixation on concanavalin A-mediated agglutinability of fixed cells with unfixed cells. We observed undiminished adherence of unfixed erythrocytes to glutaraldehyde-fixed normal and virus-transformed hamster fibroblasts coated with concanavalin A. Fixation of the erythrocytes abolished agglutination with fixed fibroblasts. The agglutinability of fixed cells is more likely related to increased cell rigidity than to decreased membrane fluidity.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)