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Science 27 June 1975:
Vol. 188. no. 4195, pp. 1316 - 1317
DOI: 10.1126/science.1145199
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Articles

Science, Vol 188, Issue 4195, 1316-1317
Copyright © 1975 by American Association for the Advancement of Science

articles

Reciprocation of renin dependency with sodium volume dependency in renal hypertension

H Gavras, HR Brunner, H Thurston, and JH Laragh

An angiotensin II inhibitor was administered to rats with two-kidney Goldblatt hypertension. The inhibitor produced a marked drop in blood pressure after 5 weeks but no significant change after 15 weeks of hypertension. However, even after 15 weeks of hypertension, following sodium depletion by either diuretics or a low sodium diet, the animals again became renin dependent as readministration of the inhibitor induced a significant fall in blood pressure. The data indicate that two-kidney Goldblatt hypertension is initially renin dependent but subsequently becomes sodium volume dependent in a way similar, although more protracted, to that already described for one-kidney Goldblatt hypertension.


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Role of Angiotensin and Its Inhibition in Hypertension, Ischemic Heart Disease, and Heart Failure.
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Models of Experimental Hypertension in Mice.
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Renin, Sodium, and Vasodepressor Response to Saralasin in Renovascular and Essential Hypertension.
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Ann Intern Med 87, 176-182
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Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents.
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