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Science 27 June 1975:
Vol. 188. no. 4195, pp. 1308 - 1310
DOI: 10.1126/science.124948
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Articles

Science, Vol 188, Issue 4195, 1308-1310
Copyright © 1975 by American Association for the Advancement of Science

articles

HL-A LD (lymphocyte defined) typing: a rapid assay with primed lymphocytes

MJ Sheehy, PM Sondel, ML Bach, R Wank, and FH Bach

When human lymphocytes are cultured for 9 to 14 days with stimulating cells of a family member differing by a single HL-A haplotype they become "primed" to recognize specific HL-A LD (mixed lymphocyte culture) antigens. These primed lymphocytes respond specifically and rapidly when "restimulated" with cells of a person that contain the same LD antigens as those of the priming haplotype. Specific HL-A LD antigens can be detected within 24 hours by this primed LD typing.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lymphocyte-defined loci in cattle.
W. Usinger, M Curie-Cohen, and W. Stone (1977)
Science 196, 1017-1018
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Polymorphic B-cell Determinants in Man.
J. J. van Rood, A. van Leeuwen, M. Jonker, A. Termijtelen, and B. A. Bradley (1977)
Cold Spring Harb Symp Quant Biol 41, 417-427
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Cellular Recognition of Major Histocompatibility Complex Antigens.
F. H. Bach, M. L. Bach, O. J. Kuperman, H. W. Sollinger, and P. M. Sondel (1977)
Cold Spring Harb Symp Quant Biol 41, 429-441
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