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Science 20 June 1975:
Vol. 188. no. 4194, pp. 1215 - 1216
DOI: 10.1126/science.1145193
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Articles

Science, Vol 188, Issue 4194, 1215-1216
Copyright © 1975 by American Association for the Advancement of Science

articles

Flavonoids as inhibitors of lens aldose reductase

SD Varma, I Mikuni, and JH Kinoshita

Flavonoids are effective inhibitors of lens aldose reductase. Quercetin, quercitrin, and myricitrin are significantly more potent than the previously known aldose reductase inhibitors. The inhibitory activity is of the noncompetitive type. In addition, quercitrin effectively blocks polyol accumulation in intact rat lenses incubated in medium containing high concentration of sugars.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Responses of Human Lens Epithelial Cells to Quercetin and DMSO.
X.-G. Cao, X.-X. Li, Y.-Z. Bao, N.-Z. Xing, and Y. Chen (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3714-3718
   Abstract »    Full Text »    PDF »
Diabetic cataracts and flavonoids.
S. Varma, A Mizuno, and J. Kinoshita (1977)
Science 195, 205-206
   Abstract »    PDF »


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