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Science 13 June 1975:
Vol. 188. no. 4193, pp. 1122 - 1123
DOI: 10.1126/science.1215990
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Articles

Science, Vol 188, Issue 4193, 1122-1123
Copyright © 1975 by American Association for the Advancement of Science

articles

Lysergic acid diethylamide: effect on histone acetylation in rabbit brain

IR Brown and CC Liew

Lysergic acid diethylamide increased acetylation of histones in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration of the drug at doses of 10 and 100 micrograms per kilogram of body weight. Evidence for the stimulation of acetylation in individual histone bands was obtained after separation by electrophoresis on polyacrylamied gels.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)