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Science 6 June 1975:
Vol. 188. no. 4192, pp. 1023 - 1025
DOI: 10.1126/science.167437
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Articles

Science, Vol 188, Issue 4192, 1023-1025
Copyright © 1975 by American Association for the Advancement of Science

articles

Immunofluorescent localization of cyclic AMP in toad urinary bladder: possible intercellular transfer

DB Goodman, FE Bloom, ER Battenberg, H Rasmussen, and WL Davis

By use of an immunofluorescent cytochemical staining technique, adenosine 3',5'-monophosphate (cyclic AMP) has been localized in toad bladder epithelial cells. Within 2 minutes after addition of vasopressin, staining intensity increases in both mitochondria-rich and granular cells. This finding, taken together with the precise anatomical relation between these two epithelial cell types and the observation that after separation of the two cell types vasopressin stimulates cyclic AMP accumulation in only mitochondria-rich cells, suggests that cyclic AMP may be transferred from mitochrondria-rich to granular cells as part of the response of the toad urinary bladder to vasopressin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The hydroosmotic response of frog urinary bladder to serosal hypertonicity is dependent on adenylate cyclase for its maintenance and affected by [Cl-]o changes.
A. T. Hanna-Mitchell and E. M. Gebruers (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R213-R223
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The metabolic code.
G. Tomkins (1975)
Science 189, 760-763
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