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Science 30 May 1975:
Vol. 188. no. 4191, pp. 945 - 947
DOI: 10.1126/science.49080
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Articles

Science, Vol 188, Issue 4191, 945-947
Copyright © 1975 by American Association for the Advancement of Science

articles

Tetanus toxin: direct evidence for retrograde intraaxonal transport

DL Price, J Griffin, A Young, K Peck, and A Stocks

The neurotoxin tetanospasmin causes tetanus when it reaches the central nervous system. In this autoradiographic study, 125-I-labeled tetanospasmin was injected into the leg muscles of rodents, and the nerves supplying these muscles were crushed. The labeled toxin accumulated within axons on the distal side of the crush. This study provides direct evidence for retrograde axonal transport of a macromolecular toxin that acts at synapses in the central nervous system.


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