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Science 30 May 1975:
Vol. 188. no. 4191, pp. 938 - 940
DOI: 10.1126/science.166432
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Articles

Science, Vol 188, Issue 4191, 938-940
Copyright © 1975 by American Association for the Advancement of Science

articles

Latent infection of sensory ganglia with herpes simplex virus: efficacy of immunization

RW Price, MA Walz, C Wohlenberg, and AL Notkins

Mice were used to test the efficacy of active immunization in preventing latent infection of local sensory ganglia that follows inoculation of superficial epithelial surfaces with herpes simplex virus. Substantial but not complete protection was observed in animals immunized and challenged with herpes simplex virus type 1, but no protection was noted in animals immunized and challenged with herpes simplex virus type 2. Latent ganglionic infection can develop in immunized animals despite the presence of high titers of neutralizing antibody.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Protective immune correlates can segregate by vaccine type in a murine herpes model system.
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In Vivo Modulation of Vaccine-Induced Immune Responses toward a Th1 Phenotype Increases Potency and Vaccine Effectiveness in a Herpes Simplex Virus Type 2 Mouse Model.
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J. Virol. 73, 501-509
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T Lymphocytes Are Required for Protection of the Vaginal Mucosae and Sensory Ganglia of Immune Mice Against Reinfection with Herpes Simplex Virus Type 2.
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Establishment of Latent Ganglionic Infection with Herpes Simplex Virus via Maxillary Gingiva and Viral Re-activation in vivo after Trauma.
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Herpes Simplex Virus Infection: Biology, Treatment, and Prevention.
S. E. STRAUS, J. F. ROONEY, J. L. SEVER, M. SEIDLIN, S. NUSINOFF-LEHRMAN, and K. CREMER (1985)
Ann Intern Med 103, 404-419
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Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice.
K. Cremer, M Mackett, C Wohlenberg, A. Notkins, and B Moss (1985)
Science 228, 737-740
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Latency of herpes simplex virus in absence of neutralizing antibody: model for reactivation.
T Sekizawa, H Openshaw, C Wohlenberg, and A. Notkins (1980)
Science 210, 1026-1028
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BCG Immunoprophylaxis of Recurrent Herpes Progenitalis.
S. M. Bierman (1976)
Arch Dermatol 112, 1410-1415
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