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Science 16 May 1975:
Vol. 188. no. 4189, pp. 740 - 741
DOI: 10.1126/science.1124397
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Articles

Science, Vol 188, Issue 4189, 740-741
Copyright © 1975 by American Association for the Advancement of Science

articles

Mechanism of insulin-induced paralysis of muscles from potassium-depleted rats

I Kao and AM Gordon

Zinc-free insulin elicited a reduction in the potassium conductance of muscle fibers from potassium-depleted muscle, which led to depolarization, blockage of action-poteintial mechanism, and paralysis. These changes are proposed as the mechanism of insulin-induced paralysis in patients with hypokalemic periodic paralysis. A similar effect by concanavalin a suggests that the effect may be mediated through the insulin receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin acts in hypokalemic periodic paralysis by reducing inward rectifier K current.
R. L. Ruff (1999)
Neurology 53, 1556
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Thyrotoxic Periodic Paralysis: Report of 10 Cases and Review of Electromyographic Findings.
D. E. Kelley, H. Gharib, F. P. Kennedy, R. J. Duda Jr, and P. G. McManis (1989)
Arch Intern Med 149, 2597-2600
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Myotonia and Chloride-Reply.
R. L. Barchi (1976)
Arch Neurol 33, 305
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Myotonia and Chloride.
A. H. Bretag (1976)
Arch Neurol 33, 304
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