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Science 25 April 1975:
Vol. 188. no. 4186, pp. 366 - 369
DOI: 10.1126/science.164060
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Articles

Science, Vol 188, Issue 4186, 366-369
Copyright © 1975 by American Association for the Advancement of Science

articles

Induction of neural differentiation in cultures of amphibian undetermined presumptive epidermis by cyclic AMP derivatives

HL Wahn, LE Lightbody, TT Tchen, and JD Taylor

Induction of neural differentiation in cultures of undetermined presumptive epidermis from three amphibian species was achieved by the addition of 1 millimolar dibutyryl adenosine 3',5'-monophosphate, 8-bromadenosine 3',5'-monophosphate, or adenosine C',E'-monophosphate together with theophylline. Adenosine 5'-monophosphate, adenosine 2',3'-monophosphate, dibutyryl guanosine 3',5'-monophosphate, and butyrate at 1 millimolar are ineffective. These results suggest that the action of the primary inductor or inductors may be mediated via adenosine 3',5'-monophosphate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of neurons in cultures.
M. Dichter (1975)
Science 190, 489-490
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