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Science 18 April 1975:
Vol. 188. no. 4185, pp. 268 - 270
DOI: 10.1126/science.1118728
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Articles

Science, Vol 188, Issue 4185, 268-270
Copyright © 1975 by American Association for the Advancement of Science

articles

Inhibition of immune responses in vitro by specific antiserums to Ia antigens

JA Frelinger, JE Niederhuber, and DC Shreffler

Mouse antiserums prepared against Ia antigens, which are products of I (immune response) region genes of the H-2 complex, can inhibit both primary (immunoglobulin M) and secondary (immunoglobulin G) immune responses in vitro by mouse spleen cultures to heterologous erythrocytes. Antiserums directed specifically at products of either the H-2K or H-2D loci have no effect on this response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse.
J McNicholas, M Steinmetz, T Hunkapiller, P Jones, and L Hood (1982)
Science 218, 1229-1232
   Abstract »    PDF »
Organization of the immune response genes.
J. Uhr, J. Capra, E. Vitetta, and R. Cook (1979)
Science 206, 292-297
   Abstract »    PDF »
Chemical Characterization of Products of the H-2 Complex.
J. Silver, J. M. Cecka, M. McMillan, and L. Hood (1977)
Cold Spring Harb Symp Quant Biol 41, 369-377
   Abstract »    PDF »
Serological and Functional Evidence for Further Subdivision of the I Regions of the H-2 Gene Complex.
D. C. Shreffler, C. S. David, S. E. Cullen, J. A. Frelinger, and J. E. Niederhuber (1977)
Cold Spring Harb Symp Quant Biol 41, 477-487
   Abstract »    PDF »


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