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Science 18 April 1975:
Vol. 188. no. 4185, pp. 264 - 266
DOI: 10.1126/science.164059
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Articles

Science, Vol 188, Issue 4185, 264-266
Copyright © 1975 by American Association for the Advancement of Science

articles

Insulin receptor: role in the resistance of human obesity to insulin

JM Amatruda, JN Livingston, and DH Lockwood

Large adipocytes from obese subjects have similar receptor numbers and affinities for insulin as small adipocytes from subjects of normal weight. These results indicate that the insulin insensitivity of large fat cells from obese humans occurs after the insulin-receptor interaction and might be explained by either a dilution of receptors over the cell surface or by alterations in intracellular metabolism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human Immunodeficiency Virus/Highly Active Antiretroviral Therapy-Associated Metabolic Syndrome: Clinical Presentation, Pathophysiology, and Therapeutic Strategies.
M. K. S. Leow, C. L. Addy, and C. S. Mantzoros (2003)
J. Clin. Endocrinol. Metab. 88, 1961-1976
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Insulin receptors in hepatocytes: postreceptor events mediate down regulation.
J. Caro and J. Amatruda (1980)
Science 210, 1029-1031
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Insulin receptor binding in obesity: a reassessment.
R. Misbin, J. O'Leary, and A Pulkkinen (1979)
Science 205, 1003-1004
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Erythrocytes: a new cell type for the evaluation of insulin receptor defects in diabetic humans.
T. Robinson, J. Archer, K. Gambhir, V. Hollis Jr, L Carter, and C Bradley (1979)
Science 205, 200-202
   Abstract »    PDF »
Insulin Receptor Status in Disease States of Man.
R. S. Bar and J. Roth (1977)
Arch Intern Med 137, 474-481
   Abstract »    PDF »


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