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Science 4 April 1975:
Vol. 188. no. 4183, pp. 55 - 57
DOI: 10.1126/science.46622
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Articles

Science, Vol 188, Issue 4183, 55-57
Copyright © 1975 by American Association for the Advancement of Science

articles

Chemotherapeutic drugs increase killing of tumor cells by antibody and complement

M Segerling, SH Ohanian, and T Borsos

When the ascitic forms of two antigenically distinct guinea pig hepatomas induced by diethylnitrosamine are treated in vitro with chemotherapeutic drugs, their sensitivity to killing by xenogeneic antibody plus guinea pig complement increases. The effect is dependent on drug dose, is reversible, and does not appear to be due to increased antigen expression or fixation of the early acting components of guinea pig complement.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phase I Study of Anticolon Cancer Humanized Antibody A33.
S. Welt, G. Ritter, C. Williams Jr., L. S. Cohen, M. John, A. Jungbluth, E. A. Richards, L. J. Old, and N. E. Kemeny (2003)
Clin. Cancer Res. 9, 1338-1346
   Abstract »    Full Text »    PDF »
Preliminary Report of a Phase I Study of Combination Chemotherapy and Humanized A33 Antibody Immunotherapy in Patients with Advanced Colorectal Cancer.
S. Welt, G. Ritter, C. Williams Jr., L. S. Cohen, A. Jungbluth, E. A. Richards, L. J. Old, and N. E. Kemeny (2003)
Clin. Cancer Res. 9, 1347-1353
   Abstract »    Full Text »    PDF »
Correlation between lipid synthesis in tumor cells and their sensitivity to humoral immune attack.
S. Schlager and S. Ohanian (1977)
Science 197, 773-776
   Abstract »    PDF »
Immunotherapy of cancer with antibody.
H. Shin, G. Pasternack, J. Economou, R. Johnson, and M. Hayden (1976)
Science 194, 327-329
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)