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Science 28 March 1975:
Vol. 187. no. 4182, pp. 1198 - 1200
DOI: 10.1126/science.163491
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Articles

Science, Vol 187, Issue 4182, 1198-1200
Copyright © 1975 by American Association for the Advancement of Science

articles

Phosphorylation of lymphocyte nuclear acidic proteins: regulation by cyclic nucleotides

EM Johnson and JW Hadden

Guanosine 3',5'-monophosphate (cyclic GMP) and cholinergic agents stimulate incorporation of phosphate into specific nuclear acidic proteins of horse peripheral blood lymphocytes. Agents that raise intracellular adenosine 3',5'-monophosphate (cyclic AMP) inhibit nuclear acidic protein phosphorylation. The opposing effects of cyclic GMP and cyclic AMP upon nuclear protein phosphorylation parallel the effects of the cyclic nucleotides upon induction of lymphocyte proliferation.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)