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Science 28 March 1975:
Vol. 187. no. 4182, pp. 1196 - 1198
DOI: 10.1126/science.46621
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Articles

Science, Vol 187, Issue 4182, 1196-1198
Copyright © 1975 by American Association for the Advancement of Science

articles

Elevated salivary and synovial fluid beta2-microglobulin in Sjogren's syndrome and rheumatoid arthritis

N Talal, HM Grey, N Zvaifler, JP Michalski, and TE Daniels

Beta2-Microglobulin is normally present in low concentrations in serum and other bodily fluids. By use of a radioimmunoassay, elevated concentrations of beta2--microglobulin were found in saliva and synovial fluid from patients with Sjogren's syndrome and rheumatoid arthritis, autoimmune inflammatory diseases that attack and destroy the salivary glands and articular tissues, respectively. Elevated beta2-microglobulin concentrations decreased in the saliva of two patients who simultaneously showed a clinical response to systemic treatment. Measurement of beta2-microglobulin in inflammatory fluids may offer a simple method of quantifying local activity in autoimmune states.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Correlation of serum B lymphocyte stimulator and {beta}2 microglobulin with autoantibody secretion and systemic involvement in primary Sjogren's syndrome.
J-E Gottenberg, M Busson, J Cohen-Solal, F Lavie, K Abbed, R P Kimberly, J Sibilia, and X Mariette (2005)
Ann Rheum Dis 64, 1050-1055
   Abstract »    Full Text »    PDF »
Sjogren's Syndrome: Association of Anti-Ro(SS-A) Antibodies with Vasculitis, Hematologic Abnormalities, and Serologic Hyperreactivity.
E. L. ALEXANDER, F. C. ARNETT, T. T. PROVOST, and M. B. STEVENS (1983)
Ann Intern Med 98, 155-159
   Abstract »    PDF »


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