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Science 21 March 1975:
Vol. 187. no. 4181, pp. 1091 - 1093
DOI: 10.1126/science.1167702
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Articles

Science, Vol 187, Issue 4181, 1091-1093
Copyright © 1975 by American Association for the Advancement of Science

articles

Chromosome-wide event accompanies the expression of recessive mutations in tetraploid cells

LA Chasin and G Urlaub

Mutants resistant to 6-thioguanine were induced in pseudotetraploid hybrid Chinese hamster cells homozygous wild-type at the locus for hypoxanthine phophoribosyl transferase but heterozygous for the linked marker glucose-6-phosphate dehydrogenase. About half of these mutants had concomitantly lost the wild-type allele for glucose-6-phosphate dehydrogenase, as expected if mutation plus chromosome segregation had occurred.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HLA variants of cultured human lymphoid cells: evidence for mutational origin and estimation of mutation rate.
D Pious and C Soderland (1977)
Science 197, 769-771
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