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Science 21 March 1975:
Vol. 187. no. 4181, pp. 1086 - 1087
DOI: 10.1126/science.1114337
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Articles

Science, Vol 187, Issue 4181, 1086-1087
Copyright © 1975 by American Association for the Advancement of Science

articles

Inhibition of catecholamine release by tolbutamide and other sulfonylureas

CY Hsu, G Brooker, MJ Peach, and TC Westfall

Tolbutamide and other sulfonylureas inhibited spontaneous and nicotine-induced release of catecholamines from the perfused cat adrenal gland and nicotine-induced release of [3-H]norepinephrine from isolated guinea pig hearts. Of the sulfonylureas tested, the order to potency of this inhibitory effect paralled the hypoglycemic action. These results raise the possibility that the inhibition of the sympathoadrenal system may contribute in part to the hypoglycemic action of sulfonylureas.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)