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Science 14 March 1975:
Vol. 187. no. 4180, pp. 963 - 965
DOI: 10.1126/science.167436
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Articles

Science, Vol 187, Issue 4180, 963-965
Copyright © 1975 by American Association for the Advancement of Science

articles

Changes in protein levels in perfusates of freely moving cats: relation to behavioral state

RR Drucker-Colin, CW Spanis, CW Cotman, and JL McGaugh

Perfusates from the brains of freely moving cats, obtained by means of a push-pull cannula, contain high concentrations of proteins. The levels vary in a cyclic fashion and are higher during rapid eye movement sleep than during the waking state. The proteins represent a distinctive class of tissue protein and their changing levels appear to reflect an alteration in the protein content of the extracellular space of brain related to behavioral state.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Molecular Window on Sleep: Changes in Gene Expression between Sleep and Wakefulness.
C. Cirelli (2005)
Neuroscientist 11, 63-74
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Science. ISSN 0036-8075 (print), 1095-9203 (online)