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Science 14 March 1975:
Vol. 187. no. 4180, pp. 951 - 953
DOI: 10.1126/science.49925
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Articles

Science, Vol 187, Issue 4180, 951-953
Copyright © 1975 by American Association for the Advancement of Science

articles

Myelination inhibiting and neuroelectric blocking factors in experimental allergic encephalomyelitis

FJ Seil, ME Smith, AL Leiman, and JM Kelly 3rd

Sensitization of Lewis rats with whole central nervous system tissue or with purified myelin induced both experimental allergic encephalomyelitis (EAE) and a serum factor which inhibited myelin formation in vitro. Sensitization with the encephalitogenic factor, myelin basic protein, induced EAE, but not the myelination inhibition factor. Sensitization with cerebroside induced neither EAE nor myelination inhibition factor. The serums from control animals without EAE as well as from animals sensitized with all of the above antigens blocked evoked electrical responses in vitro.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Synthetic galactocerebrosides evoke myelination-inhibiting antibodies.
S Hruby, E. Alvord Jr, and F. Seil (1977)
Science 195, 173-175
   Abstract »    PDF »
Neuroelectric Blocking Factors in Multiple Sclerosis and Normal Human Sera.
F. J. Seil, A. L. Leiman, and J. M. Kelly III (1976)
Arch Neurol 33, 418-422
   Abstract »    PDF »


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