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Science 7 March 1975:
Vol. 187. no. 4179, pp. 853 - 855
DOI: 10.1126/science.234627
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Articles

Science, Vol 187, Issue 4179, 853-855
Copyright © 1975 by American Association for the Advancement of Science

articles

Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine

RJ Wyatt, E Erdelyi, DoAmaral JR, GR Elliott, J Renson, and JD Barchas

An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido[3,4-b]indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Platelet Methylene Reductase Activity in Schizophrenia.
P. A. Berger, G. R. Elliott, E. Erdelyi, S. J. Watson, R. J. Wyatt, and J. D. Barchas (1977)
Arch Gen Psychiatry 34, 808-809
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Science. ISSN 0036-8075 (print), 1095-9203 (online)