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Science 7 March 1975:
Vol. 187. no. 4179, pp. 849 - 850
DOI: 10.1126/science.1114331
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Articles

Science, Vol 187, Issue 4179, 849-850
Copyright © 1975 by American Association for the Advancement of Science

articles

Conjugal transfer of a chromosomal gene determining production of enterotoxin in vibrio cholerae

ML Vasil, RK Holmes, and RA Finkelstein

Matings between strains of Vibrio cholerae differing in toxinogenicity, nutritional requirements, and antibiotic susceptibilities were performed in order to determine the location of the gene tox that controls production of cholera enterotoxin. Segregation analysis shows that tox is linked to a gene required for histidine biosynthesis. Our data indicate that the tox gene is located on the bacterial chromosome and not on a plasmid in the strains of V. cholerae studied.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)