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Science 7 March 1975:
Vol. 187. no. 4179, pp. 845 - 847
DOI: 10.1126/science.163488
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Articles

Science, Vol 187, Issue 4179, 845-847
Copyright © 1975 by American Association for the Advancement of Science

articles

Cyclic AMP and cyclic GMP may mediate opposite neuronal responses in the rat cerebral cortex

TW Stone, DA Taylor, and FE Bloom

Electrophysiologically identified pyramidal tract neurons in the rat cerebral cortex were tested with norepinephrine, acetylcholine, adenosine 3',5'-monophosphate (cyclic AMP), and guanosine 3',5'-monophosphate (cyclic GMP) applied by microiontophoresis. The neurons were usually inhibited by norepinephrine and cyclic AMP, but excited by acetylcholine and cyclic GMP. These opposing responses of pyramidal tract neurons to cyclic AMP and cyclic GMP suggests that these two nucleotides could function as reciprocal intracellular second messengers for norepinephrine and acetylcholine, respectively.


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