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Science 28 February 1975:
Vol. 187. no. 4178, pp. 746 - 748
DOI: 10.1126/science.1090001
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Articles

Science, Vol 187, Issue 4178, 746-748
Copyright © 1975 by American Association for the Advancement of Science

articles

Ventral medial hypothalamus: involvement in hypoglycemic convulsions

KJ Kellar, AE Langley, BH Marks, and JJ O'Neill

After the ventral medial hypothalamus of mice was lesioned with gold thioglucose, the dose of insulin required to produce convulsions in 50 percent of the animals was doubled compared to that in nonlesionad controls. No dose of insulin, up to 50 milliunits per gram, produced convulsions in more than 60 percent of the lesioned mice, even though blood glucose levels fell to approximately 24 milligram percent.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)