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Science 28 February 1975:
Vol. 187. no. 4178, pp. 744 - 746
DOI: 10.1126/science.1114320
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Articles

Science, Vol 187, Issue 4178, 744-746
Copyright © 1975 by American Association for the Advancement of Science

articles

Intestinal metabolism of phenacetin in the rat: effect of charcoal-broiled beef and rat chow

EJ Pantuck, KC Hsiao, R Kuntzman, and AH Conney

The intestinal metabolism of phenacetin in vitro was increased 1100 percent in rats fed charcoal-broiled ground beef in a semisynthetic diet. The intestinal metabolism of phenacetin was increased 200 percent in rats fed a chow diet, as compared to rats fed the semisynthetic diet. The results obtained suggest a need for studies in man to determine whether charcoal-broiled meat and other dietary constituents can stimulate the intestinal metabolism of phenacetin or other drugs and thereby decrease their absorption and bioavailability.


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JPEN J Parenter Enteral Nutr 11, 119-123
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Effect of charcoal-broiled beef on phenacetin metabolism in man.
E. Pantuck, K. Hsiao, A. Conney, W. Garland, A Kappas, K. Anderson, and A. Alvares (1976)
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