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Science 14 February 1975:
Vol. 187. no. 4176, pp. 547 - 549
DOI: 10.1126/science.1114313
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Articles

Science, Vol 187, Issue 4176, 547-549
Copyright © 1975 by American Association for the Advancement of Science

articles

Increased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward

RA Yokel and RA Wise

Low and high doses of a dopamine blocking agent had effects on lever pressing for intravenous amphetamine reward which resembled the effects of reward reduction and reward termination, respectively. Noradrenaline blockade had no such effects. A role in central mediation of reward perception is suggested for dopamine but not for noradrenaline.


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