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Science 14 February 1975:
Vol. 187. no. 4176, pp. 542 - 544
DOI: 10.1126/science.803708
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Articles

Science, Vol 187, Issue 4176, 542-544
Copyright © 1975 by American Association for the Advancement of Science

articles

Toxicology and pharmacological action of anabaena flos-aquae toxin

WW Carmichael, DF Biggs, and PR Gorham

Calves, rats, ducks, and goldfish given lethal oral doses of bacteria-free lyophilized cell suspensions of toxic Anabaena flos-aquae died as a result of respiratory arrest. Experiments with selected animals and pharmacological preparations showed that the main effect of the toxin was production of a sustained postsynaptic depolarizing neuromuscular blockade.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)