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Science 14 February 1975:
Vol. 187. no. 4176, pp. 540 - 542
DOI: 10.1126/science.1167256
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Articles

Science, Vol 187, Issue 4176, 540-542
Copyright © 1975 by American Association for the Advancement of Science

articles

Folate transport by the choroid plexus in vitro

R Spector and AV Lorenzo

Reduced folates are transported from blood into cerebrospinal fluid against a concentration gradient. In vitro, folates were transported into and released by isolated rabbit choroid plexuses. The choroid plexus uptake mechanism was specific for folates, energy dependent, and depressed by cold temperatures. In vivo, the choroid plexus may transport folates from blood to cerebrospinal fluid.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Role for the Proton-coupled Folate Transporter (PCFT-SLC46A1) in Folate Receptor-mediated Endocytosis.
R. Zhao, S. H. Min, Y. Wang, E. Campanella, P. S. Low, and I. D. Goldman (2009)
J. Biol. Chem. 284, 4267-4274
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SPECT Study of Folate Receptor-Positive Malignant and Normal Tissues in Mice Using a Novel 99mTc-Radiofolate.
C. Muller, F. Forrer, R. Schibli, E. P. Krenning, and M. de Jong (2008)
J. Nucl. Med. 49, 310-317
   Abstract »    Full Text »    PDF »
Leukotriene C4 transport by the choroid plexus in vitro.
R Spector and E. Goetzl (1985)
Science 228, 325-327
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