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Science 7 February 1975:
Vol. 187. no. 4175, pp. 449 - 450
DOI: 10.1126/science.163039
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Articles

Science, Vol 187, Issue 4175, 449-450
Copyright © 1975 by American Association for the Advancement of Science

articles

Endogenous cyclic adenosine monophosphate in tissues of rabbits fed an atherogenic diet

JM Augustyn and FD Ziegler

Rabbits fed a high cholesterol diet experienced a significant increase in plasma adenosine 3,5-monophosphate (cyclic AMP), which was simultaneous with the increase in plasma cholesterol. The content of cyclic AMP in atherosclerotic lesion areas of rabbit aortic intima-media was significantly higher (0.24 picomole per microgram of DNA) than that in adjacent nonlesion areas or in aortic intima-dedia from control animals (0.09 picomole per microgram of DNA). The cyclic AMP content of heart, liver, skeletal muscle, and diaphragm showed no significant elevation in animals fed cholesterol.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
cAMP Stimulates Osteoblast-like Differentiation of Calcifying Vascular Cells. POTENTIAL SIGNALING PATHWAY FOR VASCULAR CALCIFICATION.
Y. Tintut, F. Parhami, K. Bostrom, S. M. Jackson, and L. L. Demer (1998)
J. Biol. Chem. 273, 7547-7553
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Science. ISSN 0036-8075 (print), 1095-9203 (online)