Science, Vol 187, Issue 4175, 447-449
Copyright © 1975 by American Association for the Advancement of Science
Growth hormone: independent release of big and small forms from rat pituitary in vitro
ME Stachura
and
LA Frohman
Sequential release of big and small forms of growth hormone by perifused rat pituitaries has been demonstrated by immunoprecipitation. The results suggest that either the two forms are independently synthesized and released, or that a newly synthesized molecule of big growth hormone follows one of two paths: direct release or intracellular processing through the storage compartment with conversion to small growth hormone.