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Science 7 February 1975:
Vol. 187. no. 4175, pp. 443 - 445
DOI: 10.1126/science.1167428
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Articles

Science, Vol 187, Issue 4175, 443-445
Copyright © 1975 by American Association for the Advancement of Science

articles

Morphine-dependent rats: blockade of precipitated abstinence by tetrahydrocannabinol

B Hine, E Friedman, M Torrelio, and S Gershon

Male rats were implanted subcutaneously with a pellet containg 75 milligrams of morphine base or placebo, and naloxone hydrochloride (4 milligrams per kilogram of body weight) was administered 72 hours later. Treatment with delta-9-tetrahydrocannabinol (2, 5, or 10 milligrams per kilogram) 1 hour before maloxone administration significantly reduced the intensity of abstinence; the two higher doses blocked the appearance of wet shakes and escapes, diarrhea, and increased defecation. delta-9-Tetrahydrocannabinol did not induce abstinence itself, and prior treatment with cannabidiol was ineffective in reducing naloxoneprecipitated abstinence in animals with morphine pellets. These data suggest that delta-9-tetrahydrocannabinol may be of value in facilitating narcotic detoxification.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Modulation of Oral Morphine Antinociceptive Tolerance and Naloxone-Precipitated Withdrawal Signs by Oral {Delta}9-Tetrahydrocannabinol.
D. L. Cichewicz and S. P. Welch (2003)
J. Pharmacol. Exp. Ther. 305, 812-817
   Abstract »    Full Text »    PDF »
Cannabis and the brain.
L. Iversen (2003)
Brain 126, 1252-1270
   Abstract »    Full Text »    PDF »
Absence of Delta -9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice.
A. Zimmer, E. Valjent, M. Konig, A. M. Zimmer, P. Robledo, H. Hahn, O. Valverde, and R. Maldonado (2001)
J. Neurosci. 21, 9499-9505
   Abstract »    Full Text »    PDF »
Opioid and Cannabinoid Modulation of Precipitated Withdrawal in Delta 9-Tetrahydrocannabinol and Morphine-Dependent Mice.
A. H. Lichtman, S. M. Sheikh, H. H. Loh, and B. R. Martin (2001)
J. Pharmacol. Exp. Ther. 298, 1007-1014
   Abstract »    Full Text »
Functional Interaction between Opioid and Cannabinoid Receptors in Drug Self-Administration.
M. Navarro, M. R. A. Carrera, W. Fratta, O. Valverde, G. Cossu, L. Fattore, J. A. Chowen, R. Gomez, I. del Arco, M. A. Villanua, et al. (2001)
J. Neurosci. 21, 5344-5350
   Abstract »    Full Text »    PDF »
Cannabinoids and the gastrointestinal tract.
R G PERTWEE (2001)
Gut 48, 859-867
   Abstract »    Full Text »    PDF »
CB1 Receptor Antagonist Precipitates Withdrawal in Mice Exposed to Delta 9-Tetrahydrocannabinol.
S. A. Cook, J. A. Lowe, and B. R. Martin (1998)
J. Pharmacol. Exp. Ther. 285, 1150-1156
   Abstract »    Full Text »


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