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Science 24 January 1975:
Vol. 187. no. 4173, pp. 261 - 263
DOI: 10.1126/science.163038
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Articles

Science, Vol 187, Issue 4173, 261-263
Copyright © 1975 by American Association for the Advancement of Science

articles

Collagenase production by lymphokine-activated macrophages

LM Wahl, SM Wahl, SE Mergenhagen, and GR Martin

Macrophages incubated with products (lymphokines) secreted by stimulated spleen cells produced collagenase. Active lymphokines were obtained both from mitogen- and antigen-stimulated lymphocytes. These observations suggest that the degradation of collagen in chronic inflammatory lesions may be caused by macrophage collagenase.


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