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Science 17 January 1975:
Vol. 187. no. 4172, pp. 179 - 181
DOI: 10.1126/science.163036
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Articles

Science, Vol 187, Issue 4172, 179-181
Copyright © 1975 by American Association for the Advancement of Science

articles

Adenosine 3',5'-monophosphate analogs promote a circular morphology of cultured Schwannoma cells

Sheppard JR, TH Hudson, and Larson JR

Dibutyryl adenosine 3',5'-monophosphate (dibutyrl cycle AMP) and 8-bromo cyclic AMP stimulated cells cultured from a rat Schwannoma to change their morphology from irregularly shaped to flattened circular and hollow circular forms within 30 minutes. The change in shape was specifically effected by analogs of cyclic AMP and cyclic AMP elevating agents, was reversible after removal of these additives, and was prevented by vinblastine and cytochalasin b, but was not affected by actinomycin D or cycloheximide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bone cells in culture: morphologic transformation by hormones.
S. Miller, A. Wolf, and C. Arnaud (1976)
Science 192, 1340-1343
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