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Science 17 January 1975:
Vol. 187. no. 4172, pp. 171 - 173
DOI: 10.1126/science.1111095
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Articles

Science, Vol 187, Issue 4172, 171-173
Copyright © 1975 by American Association for the Advancement of Science

articles

5-methyltetrahydrofolic acid is not a methyl donor for biogenic amines: enzymatic formation of formaldehyde

E Meller, H Rosengarten, AJ Friedhoff, RD Stebbins, and R Silber

Contrary to previous reports, 5-methyltetrahydrofolic acid does not mediate the methylation of dopamine to epinine. Instead, this methyl donor is degraded enzymatically to formaldehyde, which condenses with dopamine to form a tetahydoisoquinoline derivative. The latter has chromotographic characteristics very similar to those of epinine, which likely accounts for the original misidentification of the product.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine.
R. Wyatt, E Erdelyi, DoAmaral JR, G. Elliott, J Renson, and J. Barchas (1975)
Science 187, 853-855
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Science. ISSN 0036-8075 (print), 1095-9203 (online)