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Science 10 January 1975:
Vol. 187. no. 4171, pp. 27 - 35
DOI: 10.1126/science.1088926
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Articles

Science, Vol 187, Issue 4171, 27-35
Copyright © 1975 by American Association for the Advancement of Science

articles

Genetic regulation: the Lac control region

RC Dickson, J Abelson, WM Barnes, and WS Reznikoff

The nucleotide sequence of the lac promoter-operator region has been determined. The 122 base pairs comprising this region include the recognition sites for RNA polymerase, the positive regulatory protein, CAP, and the negative regulatory protein, the repressor. Identification of mutant variants of the sequence combined with the in vitro biochemical studies of others has allowed us to tentatively identify the recognition site for each of these proteins, and to suggest how CAP might act at a distance to affect the interaction of RNA polymerase with the promoter.


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