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Science 27 December 1974:
Vol. 186. no. 4170, pp. 1219 - 1221
DOI: 10.1126/science.186.4170.1219
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Articles

Microtubule-Macrotubule Transitions: Intermediates after Exposure to the Mitotic Inhibitor Vinblastine

R. K. N. Warfield 1 and G. Benjamin Bouck 1

1 Department of Biological Sciences, University of Illinois, Chicago 60680

Vinblastine treatment of microtubule protein or intact microtubules assembled in vitro produced bifilar rings and bifilar helices. Suspentsions of rings and helices were demonstrated to bind [3H]colchicine, a diagnostic property of microtubule protein. Macrotubules are suggested to consist of tightly coiled helices formed by longitudinal compacting of loosely coiled protofilament pair intermediates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Localization of Critical Histidyl Residues Required for Vinblastine-induced Tubulin Polymerization and for Microtubule Assembly.
S. S. Rai and J. Wolff (1998)
J. Biol. Chem. 273, 31131-31137
   Abstract »    Full Text »    PDF »
Localization of the Vinblastine-binding Site on beta -Tubulin.
S. S. Rai and J. Wolff (1996)
J. Biol. Chem. 271, 14707-14711
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)