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Science 27 December 1974:
Vol. 186. no. 4170, pp. 1216 - 1217
DOI: 10.1126/science.186.4170.1216
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Articles

Skin Carcinogenesis: Cholesterol-5 agr, 6 agr-Epoxide Hydrase Activity in Mouse Skin Irradiated with Ultraviolet Light

Jarvis T. Chan 1 and Homer S. Black 1

1 Department of Dermatology, Baylor College of Medicine, and Veterans Admninistration Hospital, Houston, Texas 77025

Cholesterol-5agr,6agr-epoxide hydrase activity was 96 percent greater in skin of hairless mice that were receiving suberythemic ultraviolet light irradiation for 15 weeks than in nonirradiated controls. This enzyme system, which metabolizes cholesterol-5agr,6agr-epoxide (a known carcinogen), appears to be substrateinducible and is apparently responsible for the concomitant reduction of the sterol carcinogen that occurs prior to tumor induction.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)