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Science 20 December 1974:
Vol. 186. no. 4169, pp. 1118 - 1120
DOI: 10.1126/science.186.4169.1118
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Articles

Adenosine 3',5'-Monophosphate Content in Rat Caudate Nucleus: Demonstration of Dopaminergic and Adrenergic and Receptors

Javier Forn 1, Bruce K. Krueger 1, and Paul Greengard 1

1 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510

Dopamine, apomorphine, isoproterenol, and norepinephrine each increased the concentration of adenosine 3',5'-monophosphate in slice of rat caudate nucleus. The concentrations of dopamine, apomorphine isoproterenol, and norepinephrine causing half-maximal increases were 60, 150, 0.03 and 30 micromoles per liter, respectively. The effect of dopamine was blocked by fluphenazine, a dopamine receptor antagonist, but not by propranolol, a beta-andrenergic receptor antagonist. Conversely, the effect of isoproterenol was blocked by propranolol but not by fluphenazine. The results suggest that in rat caudate nucleus there are two distinct catecholamine receptors capable of causing increased concentrations of adenosine 3',5'-monophosphate, one having the characteristic of dopamine receptor, and the other having the characteristics of beta-adrenergic receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cyclic Nucleotides, Protein Phosphorylation and Synaptic Function.
K. G. Beam and P. Greengard (1976)
Cold Spring Harb Symp Quant Biol 40, 157-168
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Science. ISSN 0036-8075 (print), 1095-9203 (online)