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Science 6 December 1974:
Vol. 186. no. 4167, pp. 929 - 932
DOI: 10.1126/science.186.4167.929
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Articles

Hemoglobin Kinetics and the Effect of Organic Phosphates

Rama Bansil 1, Judith Herzfeld 1, and H. Eugene Stanley 1

1 Harvard-MIT Program in Health Sciences and Technology and Department of Physics, Massachusetts Institute of Technology, Cambridge 02139

A kinetic model based on allosteric mechanisms of cooperativity fits the experimentally observed phosphate dependence of hemoglobin reactions. Subunit inequivalence is found to be important in analyzing hemoglobin kinetics. The observed increase in the rate of deoxygenation in the presence of organic phosphates is primarily related to the increased rate of dissociation of the second oxygen molecule.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)