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Science 29 November 1974:
Vol. 186. no. 4166, pp. 839 - 841
DOI: 10.1126/science.186.4166.839
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Articles

Inhibition of Experimental Allergic Encephalomyelitis in Rats Severely Depleted of T Cells

Nicholas K. Gonatas 1 and Jonathan C. Howard 1

1 Department of Pathology and Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia 19174

Lewis rats depleted of thymus-derived cells (B rats) failed to develop either experimental allergic encephalomyelitis or antibody against myelin basic protein. Lewis B rats reconstituted with 690 x 106 thymocytes developed experimental allergic encephalomyelitis and levels of antibody against myelin basic protein comparable to those of controls. The Lewis B rat model should be useful in the analysis of the role of thymus-derived cell populations and antibody in the induction of experimental allergic encephalomyelitis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker.
M. Waldor, S Sriram, R Hardy, L. Herzenberg, L. Herzenberg, L Lanier, M Lim, and L Steinman (1985)
Science 227, 415-417
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Science. ISSN 0036-8075 (print), 1095-9203 (online)