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Science 22 November 1974:
Vol. 186. no. 4165, pp. 748 - 750
DOI: 10.1126/science.186.4165.748
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Articles

Humoral Immunosuppressive Substance in Mice Bearing Plasmacytomas

Prasert Tanapatchaiyapong 1 and Susan Zolla 1

1 Department of Pathology, Manhattan Veterans Adminitration Hospital, and New York University Medical School, New York 10010

The mechanism by which plasmacytomas (PC) depress the primary immune response to sheep red cells was investigated by determining the ability of normal spleen cells to produce antibody when enclosed in Millipore chambers and implanted in PC-bearing mice. Chamber-enclosed normal spleen cells implanted in PC-bearing mice responded poorly to the sheep red cells when compared to similar cells enclosed in chambers and implanted in normal mice or in mice with other lymphoid and nonlymphoid tumors. The data suggest that PC-induced immune suppression is mediated by a humoral factor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Disorders of Suppressor Immunoregulatory Cells in the Pathogenesis of Immunodeficiency and Autoimmunity.
T. A. WALDMANN, R. M. BLAESE, S. BRODER, and R. S. KRAKAUER (1978)
Ann Intern Med 88, 226-238
   Abstract »    PDF »
Changes in Lymphocyte Surface Immunoglobulins in Myeloma and the Effect of an RNA-Containing Plasma Factor.
Y. CHEN, N. BHOOPALAM, V. YAKULIS, and P. HELLER (1975)
Ann Intern Med 83, 625-631
   Abstract »    PDF »


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