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Science 22 November 1974:
Vol. 186. no. 4165, pp. 738 - 739
DOI: 10.1126/science.186.4165.738
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Articles

Gamma-Aminobutyric Acid Effects on Pituitary Gonadotropin Secretion

Jerome G. Ondo 1

1 Department of Physiology, Medical University of South Carolina, Charleston 29401

Gamma-aminobutyric acid (GABA) injected into the third ventricle of male rats promotes the release of pituitary luteinizing hormone (LH) but not follicle-stimulating hormone. When GABA was injected directly into the pituitary it was ineffective in promoting LH release. This evidence suggests that GABA may play a role in controlling the discharge of hypothalamic luteinizing hormone releasing factor.


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