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Science 15 November 1974:
Vol. 186. no. 4164, pp. 640 - 643
DOI: 10.1126/science.186.4164.640
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Articles

Neonatal Tolerance Induced by Antibody against Antigen-Specific Receptor

David S. Strayer 1, Humberto Cosenza 1, William M. F. Lee 1, Donald A. Rowley 1, and Heinz Köhler 1

1 La Rabida Institute and Departments of Pathology and Biochemistry, University of Chicago, Chicago, Illinois 60649

Specific immunologic unresponsiveness is induced by injecting adult or neonatal mice with antibody against antigen-specific receptor (antireceptor antibody). Suppression in mice treated as adults lasts several weeks, and cells from these suppressed mice respond normally in culture. In contrast, unresponsiveness induced in neonatal mice is long-lasting; cells from these mice do not respond in culture and do not affect the response of normal cells. Evidently, antireceptor antibody reversibly blocks antigen receptors in adult animals, but induces unresponsiveness in neonatal mice by depleting the clone of receptor-bearing cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Neonatal Idiotypic Exposure Alters Subsequent Cytokine, Pathology, and Survival Patterns in Experimental Schistosoma mansoni Infections.
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Structure and Immunosuppression of a Cross-reactive Idiotype Associated with Anti-p-azophenylarsonate Antibodies of Strain-A Mice.
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Clonal Depletion in Neonatal Tolerance.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)