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Science 8 November 1974:
Vol. 186. no. 4163, pp. 538 - 540
DOI: 10.1126/science.186.4163.538
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Articles

Pulsatile Growth Hormone Secretion: Suppression by Hypothalamic Ventromedial Lesions and by Long-Acting Somatostatin

Joseph B. Martin 1, Leo P. Renaud 1, and Paul Brazeau Jr. 2

1 Department of Medicine, Division of Neurology, Montreal General Hosptial, and McGill University. Montreal, Quebec, Canada
2 Salk Institute for Biological Studies, La Jolla, California

Sequential blood samples, obtained from freely behaving, nonstressed male rats, showed a pulsatile pattern of growth hormone secretion with a mean interval between peaks of 68 minutes. The bursts of secretion were blocked by lesions of the hypothalamic ventromedial nuclei and by administration of a longacting preparation of synthetic somatostatin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuroendocrine Control of Growth Hormone Secretion.
E. E. Muller, V. Locatelli, and D. Cocchi (1999)
Physiol Rev 79, 511-607
   Abstract »    Full Text »    PDF »
Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat.
L. Terry, J. Willoughby, P Braseau, J. Martin, and Y Patel (1976)
Science 192, 565-567
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)