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Science 1 November 1974:
Vol. 186. no. 4162, pp. 449 - 451
DOI: 10.1126/science.186.4162.449
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Articles

Cyclic Guanosine Monophosphate: Elevation in Degenerating Photoreceptor Cells of the C3H Mouse Retina

Debora B. Farber 1 and Richard N. Lolley 1

1 Department of Anatomy, University of California School of Medicine, Los Angeles 90024, and Developmental Neurology Laboratory, Veterans Administration Hospital, Sepulveda, California 91343

As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3',5'-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.


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