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Science 25 October 1974:
Vol. 186. no. 4161, pp. 359 - 361
DOI: 10.1126/science.186.4161.359
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Articles

Neuroblastoma: Drug-Induced Differentiation Increases Proportion of Cytoplasmic RNA That Contains Polyadenylic Acid

Stephen C. Bondy 1, Kedar N. Prasad 1, and Janet L. Purdy 1

1 Departments of Neurology and Radiology, University of Colorado Medical Center, Denver 80220

The production of cytoplasmic RNA that contains polyadenylic acid is increased, relative to total cytoplasmic RNA, in a neuroblastoma clone, NBE-(A), after induction of differentiation by 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone, an inhibitor of adenosine 3',5'-monophosphate phosphodiesterase. The amount of RNA that contains polyadenylic acid in cytoplasm may be greater in such differentiated neuroblastoma cells than in proliferating control cells.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)