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Science 18 October 1974:
Vol. 186. no. 4160, pp. 274 - 275
DOI: 10.1126/science.186.4160.274
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Articles

Relation between the Major Histocompatibility (B) Locus and Autoimmune Thyroiditis in Obese Chickens

Larry D. Bacon 1, Joseph H. Kite Jr. 2, and Noel R. Rose 3

1 Department of Immunology and Microbiology, Wayne State University Schlool of Medicine, Detroit, Michigan 48201
2 Center for Immunology and Department of Microbiology, State University of New York at Buffalo 14214
3 Department of Immunology and microbiology, Wayne State Uniiversity School of Medicine

Obese strain chickens develop circulating autoantibodies to thyroglobulin and lymphocytic infiltration of their thyroids during aging. Two alleles, B1 and B4, are found with high gene frequency at the major histocompatibility (B) locus. Greater pathology and higher antibody titers are observed in B1B1 and B1B4 birds than in their B4B4 siblings.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Marek's disease: effects of B histocompatibility alloalleles in resistant and susceptible chicken lines.
W. Briles, H. Stone, and R. Cole (1977)
Science 195, 193-195
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)