Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 18 October 1974:
Vol. 186. no. 4160, pp. 269 - 272
DOI: 10.1126/science.186.4160.269
Prev | Table of Contents | Next

Articles

Aldosterone-Induced Protein in Toad Urinary Bladder

William B. Benjamin 1 and Irwin Singer 1

1 Departments of Medicine, Philadelphia Veterans Administration Hospital and the University of Pennsylvania School of Medicine, Philadelphia 19104

Simultaneous electrophysiological and biochemical experiments demonstrated a specific aldosterone-induced protein in paired urinary hemibladders isolated from the toad Bufo marinus. Whenever aldosterone stinlmulated short-circuit current, aldosterone specifically increased [35S] methionine incorporation into a low-molecular-weight protein (about 12,000). Comparative studies with dexamethasone and insulin and inhibitory studies with spironolactone and actinomycin D suggest mineralocorticoid specificity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
New ideas about aldosterone signaling in epithelia.
J. D. Stockand (2002)
Am J Physiol Renal Physiol 282, F559-F576
   Abstract »    Full Text »    PDF »
sgk Is an Aldosterone-induced Kinase in the Renal Collecting Duct. EFFECTS ON EPITHELIAL Na+ CHANNELS.
A. Naray-Fejes-Toth, C. Canessa, E. S. Cleaveland, G. Aldrich, and G. Fejes-Toth (1999)
J. Biol. Chem. 274, 16973-16978
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)