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Science 4 October 1974:
Vol. 186. no. 4158, pp. 63 - 65
DOI: 10.1126/science.186.4158.63
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Articles

Morphine and Ethanol: Selective Depletion of Regional Brain Calcium

David H. Ross 1, Miguel A. Medina 1, and H. Lee Cardenas 1

1 Departments of Pharmacology and Psychiatry, University of Texas Health Science Center, San Antonio 78284

Administration of morphine or ethanol to rats produces a decrease in regional brain calcium in vivo. This effect is selectively antagonized by the stereospecific narcotic antagonist naloxone. Reserpine and the dopamine-acetaldehyde conjugate salsolinol also produce a depletion of regional brain calcium, but only the salsolinol depletion is antagonized by naloxone. Experiments with naloxone provide evidence for two calcium-sensitive pools in the central nervous system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effect of Meptazinol and Ethanol on Human Psychomotor Performance and Mood Ratings.
G. Tedeschi, A.T. Smith, and A. Richens (1984)
Human and Experimental Toxicology 3, 37-43
   Abstract »    PDF »
Reversal of Alcoholic Coma by Naloxone.
L. J. LYON and J. ANTONY (1982)
Ann Intern Med 96, 464-465
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)