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Science 4 October 1974:
Vol. 186. no. 4158, pp. 61 - 63
DOI: 10.1126/science.186.4158.61
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Articles

Human Chromosome 21 Dosage: Effect on the Expression of the Interferon Induced Antiviral State

Y. H. Tan 1, E. L. Schneider 2, J. Tischfield 3, C. J. Epstein 4, and F. H. Ruddle 5

1 Kline Biology Tower, Yale University, New Haven, Connecticut 06520
2 Department of Pediatrics, University of California, San Francisco 94143
3 Department of Biology, Case Western Reserve University, Cleveland, Ohio 44106
4 Department of Pediatrics, University of California, San Francisco
5 Kline Biology Tower, Yale University

Human primary skin fibroblasts trisomic for chromosome 13, 18, or 21 and diploid human skin fibroblasts were induced for an antiviral response with human interferon. The cells that were trisomnic for chromosome 21 were three to seven times more sensitive to protection by human interferon than the normal diploid or trisomic 18 or 13 fibroblasts. The differential response in trisomnic 21 cells is consistent with the known assignment of the human antiviral gene to chromosome 21.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of a Domain in the beta  Subunit of the Type I Interferon (IFN) Receptor That Exhibits a Negative Regulatory Effect in the Growth Inhibitory Action of Type I IFNs.
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J. Biol. Chem. 273, 5577-5581
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Transmembrane Signaling by the alpha Subunit of the Type I Interferon Receptor Is Essential for Activation of the Jak Kinases and the Transcriptional Factor ISGF3.
O. R. Colamonici, L. C. Platanias, P. Domanski, R. Handa, K. C. Gilmour, M. O. Diaz, N. Reich, and P. Pitha-Rowe (1995)
J. Biol. Chem. 270, 8188-8193
   Abstract »    Full Text »    PDF »
An early event in the interferon-induced transmembrane signaling process.
W. Yap, T. Teo, and Y. Tan (1986)
Science 234, 355-358
   Abstract »    PDF »
The status of the gene map of the human chromosomes.
V. McKusick and F. Ruddle (1977)
Science 196, 390-405
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